Our portfolio interest is centered on B2B healthcare AI startups. We focus on technologies expanding what is possible across care delivery, clinical decision-making, and healthcare infrastructure, while remaining grounded in the broader AI healthcare ecosystem.

Clinical decision support, ambient and workflow automation, healthcare infrastructure software, applied machine learning for diagnostics and care delivery, AI-enabled medical device breakthroughs, and platforms accelerating biomedical and life sciences discovery. Our goal is to help bring the future of healthcare forward.

The name Cold Harbor emerged during early discussions about the firm’s vision, direction, and identity. It took shape while reflecting on the hardships faced by those who pursued a new life centuries ago, from early settlers arriving in the Americas three to four hundred years ago to later waves of Italian, German, and Irish immigrants entering through Ellis Island during the cold winters of New York City.

They arrived with little more than a few belongings, their families, and a belief that a better life was possible. What they lacked in resources, they made up for in resilience and hope. Standing at the edge of the unknown, they faced uncertainty with resolve, and that moment became the foundation of the name Cold Harbor.

The firm sees a parallel in today’s innovators and founders. Building a company often requires leaving behind certainty in pursuit of something better, driven by belief rather than guarantees. Cold Harbor reflects that shared journey, one defined by risk, perseverance, and the courage to pursue progress despite uncertainty.

Mission:

To build what the future demands of us. To support, nuture, and grow bold healthcare technologies and limitless founders reshaping how humanity heals, connects, and endures, because progress is a responsibility, not a choice.

Vision:

To create a future where innovation and compassion move in sync, where every technological leap strengthens the human experience.

Values:

1.Conviction Over Consensus →We don’t follow trends. We back the truth. Our best investments come from original thinking, not collective comfort.

2. Human First →Technology should serve people. Every innovation we fund must enhance life, dignity, or access to wellbeing.

3.Truth in Execution → Ideas are cheap; precision is power. We value disciplined builders who deliver measurable impact.

4.Progress as Responsibility → Innovation isn’t optional. It is our duty to move humanity forward. We invest with intent, knowing that capital carries consequence.

5. Respect the Frontier →We operate where certainty ends. That is where real change begins.